Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P63133
UPID:
POK8_HUMAN
Alternative names:
HERV-K115 Pol protein; HERV-K_8p23.1 provirus ancestral Pol protein
Alternative UPACC:
P63133
Background:
The Endogenous retrovirus group K member 8 Pol protein, also known as HERV-K115 Pol protein or HERV-K_8p23.1 provirus ancestral Pol protein, plays a crucial role in the early stages of viral infection. It is responsible for converting viral RNA into double-stranded DNA, a process facilitated by its reverse transcriptase and RNase H domain. This protein is integral in integrating viral DNA into the host cell chromosome, a pivotal step in viral replication.
Therapeutic significance:
Understanding the role of Endogenous retrovirus group K member 8 Pol protein could open doors to potential therapeutic strategies. Its involvement in the early stages of viral replication makes it a promising target for antiviral drug development.