Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P63172
UPID:
DYLT1_HUMAN
Alternative names:
Protein CW-1; T-complex testis-specific protein 1 homolog
Alternative UPACC:
P63172; Q15763; Q5VTU4
Background:
Dynein light chain Tctex-type 1, also known as Protein CW-1 or T-complex testis-specific protein 1 homolog, plays a crucial role in cellular dynamics. It is a non-catalytic accessory component of the cytoplasmic dynein 1 complex, facilitating the retrograde motility of vesicles and organelles along microtubules. This protein is pivotal in apical cargo transport, neuronal morphogenesis, and mitotic spindle orientation. Its function extends to enhancing Rac1 activity, influencing neurogenesis, and potentially interacting with G-protein signaling pathways.
Therapeutic significance:
Understanding the role of Dynein light chain Tctex-type 1 could open doors to potential therapeutic strategies.