Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P68363
UPID:
TBA1B_HUMAN
Alternative names:
Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain
Alternative UPACC:
P68363; P04687; P05209; Q27I68; Q8WU19
Background:
Tubulin alpha-1B chain, also known as Alpha-tubulin ubiquitous, Tubulin K-alpha-1, and Tubulin alpha-ubiquitous chain, plays a pivotal role in cell structure and function. It is the major constituent of microtubules, essential for cell division, intracellular transport, and the maintenance of cell shape. Microtubules, composed of alpha- and beta-tubulin heterodimers, dynamically grow by adding GTP-tubulin dimers, facilitated by the GTPase activity of alpha-tubulin.
Therapeutic significance:
Understanding the role of Tubulin alpha-1B chain could open doors to potential therapeutic strategies. Its critical function in cell division and transport makes it a potential target for cancer therapy, as disrupting microtubule dynamics can inhibit cancer cell proliferation.