Focused On-demand Library for Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Our top-notch dedicated system is used to design specialised libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.

Our library stands out due to several important features:

  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.







Alternative names:

1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PtdIns(5)P-4-kinase isoform 2-beta

Alternative UPACC:

P78356; Q5U0E8; Q8TBP2


Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, also known as 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, plays a pivotal role in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. This enzyme uniquely favors GTP over ATP for PI(5)P phosphorylation, aligning its activity with physiological GTP concentrations. Its ability to sense GTP levels is crucial for metabolic adaptation, highlighting its importance in cellular processes.

Therapeutic significance:

Understanding the role of Phosphatidylinositol 5-phosphate 4-kinase type-2 beta could open doors to potential therapeutic strategies. Its involvement in regulating insulin signaling through both catalytic-dependent and independent mechanisms positions it as a key player in metabolic pathways, offering a promising target for addressing metabolic disorders.

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