Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for ion channels.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the channel in its native membrane environment in open, closed and inactivated forms and the ensemble virtual screening accounting for conformational mobility in each of these states. Tentative binding pockets are considered inside the pore, in the gating region and in the allosteric locations to cover the whole spectrum of possible mechanisms of action.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P78508
UPID:
KCJ10_HUMAN
Alternative names:
ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10
Alternative UPACC:
P78508; A3KME7; Q5VUT9; Q8N4I7; Q92808
Background:
ATP-sensitive inward rectifier potassium channel 10, also known as Kir4.1, plays a pivotal role in potassium ion transport across cell membranes. This protein is crucial for maintaining the potassium balance in the brain and kidneys, facilitating potassium buffering in glial cells and basolateral K(+) recycling in distal tubules, respectively.
Therapeutic significance:
The protein is implicated in a complex disorder marked by seizures, sensorineural deafness, ataxia, and electrolyte imbalance. Understanding the role of ATP-sensitive inward rectifier potassium channel 10 could open doors to potential therapeutic strategies for managing this multifaceted disease.