Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P82675
UPID:
RT05_HUMAN
Alternative names:
28S ribosomal protein S5, mitochondrial
Alternative UPACC:
P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4
Background:
Small ribosomal subunit protein uS5m, also known as 28S ribosomal protein S5, mitochondrial, plays a crucial role in the mitochondrial ribosome. It is part of the small ribosomal subunit and is involved in the translation of mitochondrial DNA-encoded proteins. The precise function of uS5m within the mitochondrial ribosome suggests its importance in mitochondrial protein synthesis, which is essential for cellular energy production and metabolic processes.
Therapeutic significance:
Understanding the role of Small ribosomal subunit protein uS5m could open doors to potential therapeutic strategies. Its pivotal function in mitochondrial protein synthesis makes it a potential target for addressing diseases linked to mitochondrial dysfunction.