Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P83436
UPID:
COG7_HUMAN
Alternative names:
Component of oligomeric Golgi complex 7
Alternative UPACC:
P83436; Q6UWU7
Background:
The Conserved oligomeric Golgi complex subunit 7, also known as Component of oligomeric Golgi complex 7, plays a pivotal role in maintaining normal Golgi function. This protein is essential for the proper processing and sorting of proteins, ensuring they are correctly glycosylated and directed to their destination within the cell.
Therapeutic significance:
Congenital disorder of glycosylation 2E, a multisystem disorder, is directly linked to mutations in the gene encoding this protein. The disorder showcases the critical importance of glycoprotein biosynthesis in various bodily functions, including nervous system development and immune response. Targeting the underlying genetic and biochemical pathways offers a promising avenue for therapeutic intervention.