Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P98179
UPID:
RBM3_HUMAN
Alternative names:
RNA-binding motif protein 3; RNPL
Alternative UPACC:
P98179
Background:
RNA-binding protein 3 (RNA-binding motif protein 3, RNPL) plays a crucial role in enhancing global protein synthesis, particularly under physiological and mild hypothermic temperatures. It achieves this by reducing the abundance of microRNAs when overexpressed and enhancing the phosphorylation of translation initiation factors, leading to active polysome formation. This protein's unique ability to modulate protein synthesis under varying temperature conditions underscores its significance in cellular processes.
Therapeutic significance:
Understanding the role of RNA-binding protein 3 could open doors to potential therapeutic strategies. Its pivotal function in regulating protein synthesis and microRNA abundance presents a novel avenue for exploring treatments for conditions where these processes are disrupted.