Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q00839
UPID:
HNRPU_HUMAN
Alternative names:
GRIP120; Nuclear p120 ribonucleoprotein; Scaffold-attachment factor A; p120; pp120
Alternative UPACC:
Q00839; O75507; Q8N174; Q96HY9; Q9BQ09
Background:
Heterogeneous nuclear ribonucleoprotein U (hnRNP U), also known as Scaffold-attachment factor A, plays a pivotal role in cellular processes including chromatin organization, transcription regulation, and mRNA splicing. It is essential for genomic stability, X-chromosome inactivation, and mitotic progression. Its involvement in telomere length regulation and mRNA stability underscores its multifunctionality in cell biology.
Therapeutic significance:
The association of hnRNP U with Developmental and epileptic encephalopathy 54 highlights its potential as a therapeutic target. Understanding the role of hnRNP U could open doors to potential therapeutic strategies for this severe neurological condition.