Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q00872
UPID:
MYPC1_HUMAN
Alternative names:
C-protein, skeletal muscle slow isoform
Alternative UPACC:
Q00872; B4DKR5; B7Z8G8; B7ZL02; B7ZL09; B7ZL10; E7ESM5; E7EWS6; G3XAE8; Q15497; Q17RR7; Q569K7; Q86T48; Q86TC8; Q8N3L2
Background:
Myosin-binding protein C, slow-type, also known as C-protein, skeletal muscle slow isoform, plays a pivotal role in muscle contraction. It is a thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands, binding to both myosin and actin. This protein modulates the activity of actin-activated myosin ATPase, potentially influencing muscle contraction or serving a structural role.
Therapeutic significance:
Linked to diseases such as Arthrogryposis, distal, 1B, Lethal congenital contracture syndrome 4, and Congenital myopathy 16, Myosin-binding protein C, slow-type's genetic variants underscore its clinical importance. Understanding its role could open doors to potential therapeutic strategies, offering hope for targeted interventions in these muscular disorders.