Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q01968
UPID:
OCRL_HUMAN
Alternative names:
Inositol polyphosphate 5-phosphatase OCRL-1; Lowe oculocerebrorenal syndrome protein; Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
Alternative UPACC:
Q01968; A6NKI1; A8KAP2; B7ZLX2; O60800; Q15684; Q15774; Q4VY09; Q4VY10; Q5JQF1; Q5JQF2; Q9UJG5; Q9UMA5
Background:
Inositol polyphosphate 5-phosphatase OCRL, also known as Lowe oculocerebrorenal syndrome protein, plays a pivotal role in cellular processes by hydrolyzing phosphatidylinositol phosphates. Its activity is crucial for regulating endosomal trafficking, primary cilia assembly, and phagocytosis through modulation of PI3K signaling.
Therapeutic significance:
OCRL is directly implicated in Lowe oculocerebrorenal syndrome and Dent disease 2, conditions marked by eye, nervous system, and kidney abnormalities. Targeting OCRL's enzymatic function offers a promising avenue for therapeutic intervention in these genetic disorders.