Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q02548
UPID:
PAX5_HUMAN
Alternative names:
B-cell-specific transcription factor
Alternative UPACC:
Q02548; A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; O75933; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732
Background:
Paired box protein Pax-5, also known as B-cell-specific transcription factor, is pivotal in the development of B-lymphocytes. It regulates the transition of lymphoid progenitors to the B-cell lineage by repressing inappropriate genes while activating specific ones, thus influencing cell adhesion, migration, and the maturation of B-cells. Additionally, Pax-5 plays a crucial role in maintaining Epstein-Barr virus genome copy number and inhibiting lytic reactivation.
Therapeutic significance:
Given its essential role in B-cell development and its association with acute lymphoblastic leukemia, a common childhood malignancy, Pax-5 presents a promising target for therapeutic intervention. Understanding the role of Paired box protein Pax-5 could open doors to potential therapeutic strategies, especially in the context of leukemia and viral infections.