Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q02846
UPID:
GUC2D_HUMAN
Alternative names:
CG-E; Guanylate cyclase 2D, retinal; Rod outer segment membrane guanylate cyclase
Alternative UPACC:
Q02846; Q6LEA7
Background:
Retinal guanylyl cyclase 1, also known as Guanylate cyclase 2D, retinal, plays a pivotal role in the phototransduction pathway by catalyzing the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. This enzyme is crucial for replenishing cGMP, essential for normal vision, and may also assist in the trafficking of proteins to the photoreceptor outer segment membrane.
Therapeutic significance:
Given its central role in vision, mutations in Retinal guanylyl cyclase 1 are linked to several inherited retinal dystrophies, including Leber congenital amaurosis 1, Cone-rod dystrophy 6, and others. Understanding the function and regulation of this protein could lead to novel therapeutic strategies for these blinding diseases.