Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q02978
UPID:
M2OM_HUMAN
Alternative names:
Solute carrier family 25 member 11
Alternative UPACC:
Q02978; F5GY65; O75537; Q969P7
Background:
The Mitochondrial 2-oxoglutarate/malate carrier protein, also known as Solute carrier family 25 member 11, plays a crucial role in cellular metabolism. It facilitates the transport of 2-oxoglutarate across the inner mitochondrial membrane, exchanging it for malate and other dicarboxylic acids. This protein is integral to the malate-aspartate shuttle, gluconeogenesis from lactate, and nitrogen metabolism. It also maintains mitochondrial dynamics and protects against cytotoxic-induced apoptosis by modulating glutathione levels.
Therapeutic significance:
Given its involvement in Paragangliomas 6, a tumor predisposition syndrome, understanding the role of the Mitochondrial 2-oxoglutarate/malate carrier protein could unveil new therapeutic strategies. Its function in metabolic processes and mitochondrial integrity suggests potential targets for intervention in metabolic disorders and cancer.