Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q03252
UPID:
LMNB2_HUMAN
Alternative names:
-
Alternative UPACC:
Q03252; O75292; Q14734; Q96DF6
Background:
Lamin-B2, encoded by the gene with accession number Q03252, is a pivotal component of the nuclear lamina. This fibrous layer, located on the nucleoplasmic side of the inner nuclear membrane, plays a crucial role in providing structural support to the nuclear envelope and potentially interacts with chromatin, influencing genetic expression.
Therapeutic significance:
Lamin-B2 is implicated in several diseases, including Partial acquired lipodystrophy, Epilepsy, progressive myoclonic 9, and Microcephaly 27, primary, autosomal dominant. These associations highlight its critical role in cellular function and underscore the potential for targeted therapeutic strategies aimed at mitigating these conditions.