Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q04609
UPID:
FOLH1_HUMAN
Alternative names:
Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase
Alternative UPACC:
Q04609; A4UU12; A9CB79; B7Z312; B7Z343; D3DQS5; E9PDX8; O43748; Q16305; Q541A4; Q8TAY3; Q9NP15; Q9NYE2; Q9P1P8
Background:
Glutamate carboxypeptidase 2 (GCPII) is a multifunctional protein with critical roles in various biological processes, including folate absorption and neurotransmission modulation. Known by several names such as Folate hydrolase 1 and Prostate-specific membrane antigen, it exhibits folate hydrolase and NAALADase activity, crucial for folate uptake in the intestine and modulating excitatory neurotransmission in the brain by hydrolyzing NAAG.
Therapeutic significance:
Understanding the role of Glutamate carboxypeptidase 2 could open doors to potential therapeutic strategies. Its involvement in modulating neurotransmission and folate uptake presents a unique opportunity for developing treatments targeting neurological conditions and enhancing nutrient absorption.