Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q04671
UPID:
P_HUMAN
Alternative names:
Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog
Alternative UPACC:
Q04671; Q15211; Q15212; Q96EN1; Q9UMI5
Background:
The P protein, also known as Melanocyte-specific transporter protein or Pink-eyed dilution protein homolog, plays a crucial role in melanogenesis. It contributes to a melanosome-specific anion current, modulating melanosomal pH for optimal tyrosinase activity, essential for melanin synthesis and melanosome maturation. This protein is a key determinant in the variation of skin and eye color across different ethnicities.
Therapeutic significance:
Given its pivotal role in melanogenesis, the P protein's dysfunction is linked to Albinism, oculocutaneous, 2, a disorder characterized by reduced melanin in skin, hair, and eyes. Understanding the role of P protein could open doors to potential therapeutic strategies for treating pigmentary disorders.