Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q0VGL1
UPID:
LTOR4_HUMAN
Alternative names:
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
Alternative UPACC:
Q0VGL1
Background:
Ragulator complex protein LAMTOR4, also known as Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4, plays a pivotal role in amino acid sensing and the activation of mTORC1. This process is crucial for cell growth in response to various stimuli including growth factors, energy levels, and amino acids. LAMTOR4, as part of the Ragulator complex, facilitates the activation of Rag GTPases and their recruitment to the lysosome membrane, thereby acting as a scaffold for mTORC1 activation.
Therapeutic significance:
Understanding the role of Ragulator complex protein LAMTOR4 could open doors to potential therapeutic strategies.