Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q10567
UPID:
AP1B1_HUMAN
Alternative names:
Adaptor protein complex AP-1 subunit beta-1; Adaptor-related protein complex 1 subunit beta-1; Beta-1-adaptin; Beta-adaptin 1; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit
Alternative UPACC:
Q10567; C9JRD1; F8WDL0; P78436; Q20WL3; Q86X54
Background:
AP-1 complex subunit beta-1, also known as Beta-1-adaptin, plays a crucial role in protein sorting within the late-Golgi/trans-Golgi network and endosomes. This protein is a part of the clathrin-associated adaptor protein complex 1, essential for recruiting clathrin to membranes and recognizing sorting signals in transmembrane cargo molecules.
Therapeutic significance:
The protein's involvement in Keratitis-ichthyosis-deafness syndrome, autosomal recessive, underscores its potential as a target for therapeutic intervention. Understanding the role of AP-1 complex subunit beta-1 could open doors to potential therapeutic strategies.