Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q10713
UPID:
MPPA_HUMAN
Alternative names:
Alpha-MPP; Inactive zinc metalloprotease alpha; P-55
Alternative UPACC:
Q10713; B4DKL3; E7ET61; Q16639; Q5SXM9; Q8N513
Background:
Mitochondrial-processing peptidase subunit alpha, also known as Alpha-MPP, plays a crucial role in mitochondrial biogenesis. It acts as a substrate recognition and binding subunit of the mitochondrial processing protease (MPP), essential for cleaving mitochondrial sequences from newly imported precursor proteins. This process is vital for the proper functioning of mitochondria, the powerhouse of the cell.
Therapeutic significance:
The protein is implicated in Spinocerebellar ataxia, autosomal recessive, 2 (SCAR2), a disorder characterized by impaired motor development, ataxic gait, and cognitive challenges. Understanding the role of Mitochondrial-processing peptidase subunit alpha could open doors to potential therapeutic strategies for SCAR2 and related mitochondrial dysfunctions.