Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q12765
UPID:
SCRN1_HUMAN
Alternative names:
-
Alternative UPACC:
Q12765; A8K0E9; B4DHM0; B4DIP5; C9JPG0; Q25QX7; Q8IWD1
Background:
Secernin-1 plays a pivotal role in the regulation of exocytosis in mast cells, enhancing both the extent of secretion and the sensitivity to calcium stimulation. This protein's function is crucial for the proper release of substances from cells, a process that is fundamental in various physiological and pathological contexts.
Therapeutic significance:
Understanding the role of Secernin-1 could open doors to potential therapeutic strategies. Its involvement in the regulation of exocytosis positions it as a key target for modulating immune responses and developing treatments for conditions where mast cell activity is a factor.