Focused On-demand Library for WASH complex subunit 5

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

Our top-notch dedicated system is used to design specialised libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q12768

UPID:

WASC5_HUMAN

Alternative names:

Strumpellin; WASH complex subunit strumpellin

Alternative UPACC:

Q12768; A8K4R7; Q3KQX5; Q8TBQ2

Background:

The WASH complex subunit 5, also known as Strumpellin, plays a pivotal role in cellular processes, including endosome sorting and actin polymerization. It is a key component of the WASH core complex, promoting the recruitment and activation of the Arp2/3 complex at endosome surfaces. This action is crucial for the fission of tubules, aiding in the transport intermediates during sorting. Additionally, Strumpellin is implicated in axonal outgrowth and the trafficking of specific cellular cargos.

Therapeutic significance:

Strumpellin's involvement in Spastic paraplegia 8 and Ritscher-Schinzel syndrome 1, through gene variants affecting its function, highlights its potential as a therapeutic target. Understanding the role of Strumpellin could open doors to potential therapeutic strategies for these neurodegenerative and developmental disorders.