Focused On-demand Library for WASH complex subunit 5

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We use our state-of-the-art dedicated workflow for designing focused libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.

Our library distinguishes itself through several key aspects:

The Receptor.AI platform integrates all available data about the target protein, including past experiments, literature data, known ligands, structural information and more. This consolidated approach maximises the probability of prioritising highly relevant compounds.
The platform uses sophisticated molecular simulations to identify possible binding sites so that the compounds in the focused library are suitable for discovering allosteric inhibitors and the binders for cryptic pockets.
The platform integrates over 50 highly customisable AI models, which are thoroughly tested and validated on a multitude of commercial drug discovery programs and research projects. It is designed to be efficient, reliable and accurate. All this power is utilised when producing the focused libraries.
In addition to producing the focused libraries, Receptor.AI provides services and end-to-end solutions at every stage of preclinical drug discovery. The pricing model is success-based, which reduces your risks and leverages the mutual benefits of the project's success.

partner

Reaxense

upacc

Q12768

UPID:

WASC5_HUMAN

Alternative names:

Strumpellin; WASH complex subunit strumpellin

Alternative UPACC:

Q12768; A8K4R7; Q3KQX5; Q8TBQ2

Background:

The WASH complex subunit 5, also known as Strumpellin, plays a pivotal role in cellular processes, including endosome sorting and actin polymerization. It is a key component of the WASH core complex, promoting the recruitment and activation of the Arp2/3 complex at endosome surfaces. This action is crucial for the fission of tubules, aiding in the transport intermediates during sorting. Additionally, Strumpellin is implicated in axonal outgrowth and the trafficking of specific cellular cargos.

Therapeutic significance:

Strumpellin's involvement in Spastic paraplegia 8 and Ritscher-Schinzel syndrome 1, through gene variants affecting its function, highlights its potential as a therapeutic target. Understanding the role of Strumpellin could open doors to potential therapeutic strategies for these neurodegenerative and developmental disorders.