Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It includes extensive molecular simulations of the receptor in its native membrane environment and the ensemble virtual screening accounting for its conformational mobility. In the case of dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets are determined on and between the subunits to cover the whole spectrum of possible mechanisms of action.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q13003
UPID:
GRIK3_HUMAN
Alternative names:
Excitatory amino acid receptor 5; Glutamate receptor 7
Alternative UPACC:
Q13003; A9Z1Z8; B1AMS6; Q13004; Q16136
Background:
The Glutamate receptor ionotropic, kainate 3, also known as Excitatory amino acid receptor 5 and Glutamate receptor 7, is a pivotal receptor in the central nervous system. It functions as a ligand-gated ion channel, playing a crucial role in excitatory synaptic transmission. This receptor's affinity for various ligands, including domoate, kainate, L-glutamate, quisqualate, AMPA, and NMDA, underscores its significance in neurotransmission.
Therapeutic significance:
Understanding the role of Glutamate receptor ionotropic, kainate 3 could open doors to potential therapeutic strategies. Its involvement in excitatory synaptic transmission highlights its potential as a target for developing treatments for neurological conditions.