Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q13402
UPID:
MYO7A_HUMAN
Alternative names:
-
Alternative UPACC:
Q13402; B9A011; F8VUN5; P78427; Q13321; Q14785; Q92821; Q92822
Background:
Unconventional myosin-VIIa plays a pivotal role in cellular movements and sensory functions. It is crucial for the renewal of outer photoreceptor disks in the retina, aiding in vision, and supports the organization of cochlear hair cell bundles in the inner ear, essential for hearing. This protein's involvement in vesicle trafficking suggests a broad impact on cellular health and function.
Therapeutic significance:
Given its association with Usher syndrome 1B, autosomal recessive deafness 2, and autosomal dominant deafness 11, targeting unconventional myosin-VIIa offers a promising avenue for treating sensorineural hearing loss and retinitis pigmentosa. Understanding its role could open doors to potential therapeutic strategies.