Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q13503
UPID:
MED21_HUMAN
Alternative names:
Mediator complex subunit 21; RNA polymerase II holoenzyme component SRB7
Alternative UPACC:
Q13503; B2R4I3; Q6IB05; Q92811
Background:
Mediator of RNA polymerase II transcription subunit 21, also known as Mediator complex subunit 21 and RNA polymerase II holoenzyme component SRB7, plays a pivotal role in the transcription of RNA polymerase II-dependent genes. It acts as a coactivator, facilitating the transfer of information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. By serving as a scaffold, it enables the assembly of a functional preinitiation complex.
Therapeutic significance:
Understanding the role of Mediator of RNA polymerase II transcription subunit 21 could open doors to potential therapeutic strategies.