Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q13615
UPID:
MTMR3_HUMAN
Alternative names:
FYVE domain-containing dual specificity protein phosphatase 1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 10
Alternative UPACC:
Q13615; A5PL26; A7MD32; Q9NYN5; Q9NYN6; Q9UDX6; Q9UEG3
Background:
Myotubularin-related protein 3, also known as Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, plays a crucial role in lipid signaling pathways by dephosphorylating phosphoinositides. It specifically targets phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, and may also act on proteins phosphorylated on Ser, Thr, and Tyr residues. This protein is encoded by the gene with the UniProt accession number Q13615.
Therapeutic significance:
Understanding the role of Myotubularin-related protein 3 could open doors to potential therapeutic strategies. Its involvement in lipid signaling pathways suggests a pivotal role in cellular processes, making it a target of interest in drug discovery.