Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q13753
UPID:
LAMC2_HUMAN
Alternative names:
Cell-scattering factor 140 kDa subunit; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit; Ladsin 140 kDa subunit; Laminin B2t chain; Laminin-5 subunit gamma; Large adhesive scatter factor 140 kDa subunit; Nicein subunit gamma
Alternative UPACC:
Q13753; Q02536; Q02537; Q13752; Q14941; Q14DF7; Q2M1N2; Q5VYE8
Background:
Laminin subunit gamma-2, known by various names such as Ladsin 140 kDa subunit and Epiligrin subunit gamma, plays a pivotal role in cell attachment, migration, and organization during embryonic development. It interacts with other extracellular matrix components, facilitating the assembly of cells into tissues.
Therapeutic significance:
The protein is crucial in the pathology of Epidermolysis bullosa, junctional 3A, intermediate, and Epidermolysis bullosa, junctional 3B, severe. These conditions are characterized by skin fragility and blistering due to minor trauma, with the severe form leading to early mortality. Understanding the role of Laminin subunit gamma-2 could open doors to potential therapeutic strategies for these debilitating diseases.