Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q13769
UPID:
THOC5_HUMAN
Alternative names:
Functional spliceosome-associated protein 79; NF2/meningioma region protein pK1.3; Placental protein 39.2; hTREX90
Alternative UPACC:
Q13769; O60839; Q9UPZ5
Background:
THO complex subunit 5 homolog (THOC5) is a pivotal component of the TREX complex, playing a crucial role in mRNA transcription, processing, and nuclear export. It specifically associates with spliced mRNA, facilitating its export to the cytoplasm via the TAP/NFX1 pathway. THOC5 is also involved in transcription elongation, genome stability, and alternative polyadenylation site choice. It regulates the expression of key myeloid transcription factors, contributing to hematopoietic primitive cell survival and monocytic development.
Therapeutic significance:
Understanding the role of THO complex subunit 5 homolog could open doors to potential therapeutic strategies.