Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q13797
UPID:
ITA9_HUMAN
Alternative names:
Integrin alpha-RLC
Alternative UPACC:
Q13797; Q14638
Background:
Integrin alpha-9, also known as Integrin alpha-RLC, plays a pivotal role in cell adhesion and signal transduction. It forms a receptor complex with Integrin beta-1, recognizing and binding to specific sequences in proteins such as VCAM1, cytotactin, and osteopontin. This interaction is crucial for various cellular processes, including migration, differentiation, and proliferation.
Therapeutic significance:
Understanding the role of Integrin alpha-9 could open doors to potential therapeutic strategies. Its involvement in cell adhesion and signaling pathways highlights its potential as a target for modulating disease-related processes.