Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q13950
UPID:
RUNX2_HUMAN
Alternative names:
Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; Polyomavirus enhancer-binding protein 2 alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit
Alternative UPACC:
Q13950; O14614; O14615; O95181
Background:
Runt-related transcription factor 2 (RUNX2) is a pivotal transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. It plays a crucial role in the maturation of osteoblasts and is essential for both intramembranous and endochondral ossification. RUNX2's ability to bind to various enhancers and promoters facilitates the transcription of genes critical for bone development and homeostasis.
Therapeutic significance:
RUNX2's involvement in diseases such as Cleidocranial dysplasia 1 and Metaphyseal dysplasia with maxillary hypoplasia underscores its therapeutic significance. Understanding the role of RUNX2 could open doors to potential therapeutic strategies for these skeletal disorders, highlighting the importance of targeted research in uncovering novel treatments.