Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q13956
UPID:
CNCG_HUMAN
Alternative names:
-
Alternative UPACC:
Q13956; Q52LY7
Background:
The Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma plays a pivotal role in the visual signal transmission and amplification in vertebrate rods and cones. This protein is essential for the proper functioning of phototransduction, a process critical for vision.
Therapeutic significance:
Linked to Cone dystrophy, retinal 3A, a rare eye disorder, this protein's study offers insights into novel therapeutic approaches. Understanding its function and the impact of genetic variants could lead to breakthrough treatments for this and potentially other retinal diseases.