Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q14258
UPID:
TRI25_HUMAN
Alternative names:
Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147
Alternative UPACC:
Q14258
Background:
E3 ubiquitin/ISG15 ligase TRIM25, also known as Estrogen-responsive finger protein and RING finger protein 147, plays a pivotal role in innate immune defense against viruses. It functions by mediating ubiquitination of key immune signaling molecules such as RIGI and IFIH1, facilitating the production of interferons in response to viral infection. Additionally, TRIM25 is involved in various cellular processes including signal transduction, estrogen action, and DNA replication fork restart, highlighting its multifunctional nature.
Therapeutic significance:
Understanding the role of E3 ubiquitin/ISG15 ligase TRIM25 could open doors to potential therapeutic strategies.