Focused On-demand Library for Glycerol kinase 3

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

We employ our advanced, specialised process to create targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Our library stands out due to several important features:

  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.







Alternative names:

ATP:glycerol 3-phosphotransferase 3; Glycerol kinase 3 pseudogene; Glycerol kinase, testis specific 1

Alternative UPACC:

Q14409; Q6NXP9


Glycerol kinase 3, also known as ATP:glycerol 3-phosphotransferase 3, plays a crucial role in the regulation of glycerol uptake and metabolism. This enzyme, encoded by the gene with the UniProt accession number Q14409, is alternatively named Glycerol kinase 3 pseudogene and Glycerol kinase, testis specific 1. Its primary function is to facilitate the phosphorylation of glycerol, a key step in the glycerolipid metabolism pathway.

Therapeutic significance:

Understanding the role of Glycerol kinase 3 could open doors to potential therapeutic strategies. Its involvement in glycerol metabolism suggests that it could be a target for conditions related to metabolic disorders. The exploration of this protein's function and regulation might lead to novel interventions in diseases where glycerol metabolism is disrupted.

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