Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q14416
UPID:
GRM2_HUMAN
Alternative names:
-
Alternative UPACC:
Q14416; B0M0K7; Q14CU5; Q52MC6; Q9H3N6
Background:
Metabotropic glutamate receptor 2 (mGluR2) is a crucial component in the central nervous system, acting as a G-protein coupled receptor for glutamate. This receptor plays a pivotal role in modulating neurotransmission through its ability to inhibit adenylate cyclase activity upon activation by its ligand, glutamate. Its involvement in synaptogenesis and synaptic stabilization highlights its importance in neural communication and plasticity.
Therapeutic significance:
Understanding the role of Metabotropic glutamate receptor 2 could open doors to potential therapeutic strategies. Its regulatory function in neurotransmission and synaptic activities positions it as a key target for addressing neurological disorders.