Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q14515
UPID:
SPRL1_HUMAN
Alternative names:
High endothelial venule protein; MAST 9
Alternative UPACC:
Q14515; B4E2Z0; E7ESU2; Q14800
Background:
SPARC-like protein 1, also known by its alternative names High endothelial venule protein and MAST 9, is a protein encoded by the gene with the UniProt accession number Q14515. Its role in cellular processes and molecular pathways is a subject of ongoing research, highlighting its potential significance in various biological contexts.
Therapeutic significance:
Understanding the role of SPARC-like protein 1 could open doors to potential therapeutic strategies. Its involvement in cellular mechanisms suggests a promising avenue for drug discovery, aiming to target diseases at the molecular level.