Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q14520
UPID:
HABP2_HUMAN
Alternative names:
Factor VII-activating protease; Factor seven-activating protease; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein
Alternative UPACC:
Q14520; A8K467; B7Z8U5; F5H5M6; O00663
Background:
Hyaluronan-binding protein 2, also known as Factor VII-activating protease, plays a crucial role in the coagulation cascade by activating Factor VII and converting pro-urokinase into its active form. It is unique in its ability to cleave the alpha-chain of fibrinogen without initiating fibrin clot formation or fibrinolysis directly. This protein's multifaceted role extends to cell proliferation and migration, suggesting a potential tumor suppressor function.
Therapeutic significance:
Given its association with non-medullary thyroid cancer and its pivotal role in cell proliferation and migration, Hyaluronan-binding protein 2 presents a promising target for therapeutic intervention. Understanding the role of Hyaluronan-binding protein 2 could open doors to potential therapeutic strategies, particularly in the context of thyroid cancer treatment and possibly other malignancies.