Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q14562
UPID:
DHX8_HUMAN
Alternative names:
DEAH box protein 8; RNA helicase HRH1
Alternative UPACC:
Q14562
Background:
ATP-dependent RNA helicase DHX8, also known as DEAH box protein 8 and RNA helicase HRH1, plays a crucial role in pre-mRNA splicing as a component of the spliceosome. It is instrumental in facilitating the nuclear export of spliced mRNA by releasing the RNA from the spliceosome, highlighting its essential function in RNA processing.
Therapeutic significance:
Understanding the role of ATP-dependent RNA helicase DHX8 could open doors to potential therapeutic strategies. Its pivotal function in RNA processing and export makes it a compelling target for research aimed at uncovering novel treatments.