Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q14565
UPID:
DMC1_HUMAN
Alternative names:
-
Alternative UPACC:
Q14565; A8K9A2; B4DMW6; Q08AI1; Q99498; Q9UH11
Background:
The Meiotic recombination protein DMC1/LIM15 homolog plays a pivotal role in meiotic recombination, a critical process for genetic diversity and reproduction. It specifically aids in homologous strand assimilation, essential for resolving meiotic double-strand breaks. This protein's function underscores its importance in the accurate segregation of chromosomes during meiosis.
Therapeutic significance:
Understanding the role of Meiotic recombination protein DMC1/LIM15 homolog could open doors to potential therapeutic strategies. Its involvement in the fundamental process of meiotic recombination highlights its potential as a target for interventions in genetic disorders related to meiotic errors.