AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for Metabotropic glutamate receptor 7

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We use our state-of-the-art dedicated workflow for designing focused libraries for receptors.

 Fig. 1. The sreening workflow of Receptor.AI

It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.

Our library stands out due to several important features:

  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.

partner

Reaxense

upacc

Q14831

UPID:

GRM7_HUMAN

Alternative names:

-

Alternative UPACC:

Q14831; Q8NFS2; Q8NFS3; Q8NFS4

Background:

Metabotropic glutamate receptor 7 (mGluR7) plays a pivotal role in neuronal development, primarily through the MAPK-cAMP-PKA signaling pathway. It is activated by glutamate, leading to axon outgrowth regulation. This receptor's activation inhibits adenylate cyclase via G-protein signaling, showcasing its intricate involvement in neurotransmission.

Therapeutic significance:

The association of mGluR7 with neurodevelopmental disorders, including those marked by seizures, hypotonia, and brain imaging abnormalities, underscores its therapeutic potential. Understanding the role of Metabotropic glutamate receptor 7 could open doors to potential therapeutic strategies for these debilitating conditions.

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