Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14831
UPID:
GRM7_HUMAN
Alternative names:
-
Alternative UPACC:
Q14831; Q8NFS2; Q8NFS3; Q8NFS4
Background:
Metabotropic glutamate receptor 7 (mGluR7) plays a pivotal role in neuronal development, primarily through the MAPK-cAMP-PKA signaling pathway. It is activated by glutamate, leading to axon outgrowth regulation. This receptor's activation inhibits adenylate cyclase via G-protein signaling, showcasing its intricate involvement in neurotransmission.
Therapeutic significance:
The association of mGluR7 with neurodevelopmental disorders, including those marked by seizures, hypotonia, and brain imaging abnormalities, underscores its therapeutic potential. Understanding the role of Metabotropic glutamate receptor 7 could open doors to potential therapeutic strategies for these debilitating conditions.