Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q14974
UPID:
IMB1_HUMAN
Alternative names:
Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit
Alternative UPACC:
Q14974; B7ZAV6; D3DTT3; Q14637; Q53XN2; Q96J27
Background:
Importin subunit beta-1, also known as Importin-90, Karyopherin subunit beta-1, Nuclear factor p97, and Pore targeting complex 97 kDa subunit, plays a crucial role in nuclear protein import. It functions either in association with an adapter protein, like an importin-alpha subunit, or autonomously as a nuclear transport receptor. This protein is essential for the nuclear import of ribosomal proteins and histones, and in the context of HIV-1 infection, it mediates the nuclear import of HIV-1 Rev.
Therapeutic significance:
Understanding the role of Importin subunit beta-1 could open doors to potential therapeutic strategies.