Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q14CM0
UPID:
FRPD4_HUMAN
Alternative names:
PDZ domain-containing protein 10; PSD-95-interacting regulator of spine morphogenesis
Alternative UPACC:
Q14CM0; A8K0X9; O15032
Background:
FERM and PDZ domain-containing protein 4, also known as PDZ domain-containing protein 10 or PSD-95-interacting regulator of spine morphogenesis, plays a crucial role in the nervous system. It acts as a positive regulator of dendritic spine morphogenesis and density, essential for maintaining excitatory synaptic transmission. This protein's interaction with phosphatidylinositol 4,5-bisphosphate highlights its significance in cellular signaling pathways.
Therapeutic significance:
Linked to Intellectual developmental disorder, X-linked 104, FERM and PDZ domain-containing protein 4's study offers insights into intellectual disability's genetic basis. Understanding its role could pave the way for innovative therapeutic strategies targeting synaptic malfunctions in intellectual disabilities.