Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14CN2
UPID:
CLCA4_HUMAN
Alternative names:
Calcium-activated chloride channel family member 4; Calcium-activated chloride channel protein 2; Chloride channel accessory 4
Alternative UPACC:
Q14CN2; A8MQC9; B7Z1Q5; Q6UX81; Q9UNF7
Background:
Calcium-activated chloride channel regulator 4, also known as Calcium-activated chloride channel family member 4, Calcium-activated chloride channel protein 2, and Chloride channel accessory 4, plays a crucial role in mediating calcium-activated chloride conductance. This protein's involvement in cellular processes highlights its importance in maintaining physiological balance.
Therapeutic significance:
Understanding the role of Calcium-activated chloride channel regulator 4 could open doors to potential therapeutic strategies. Its pivotal function in chloride conductance suggests its potential as a target in treating diseases where chloride ion dysregulation is a factor.