Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q15019
UPID:
SEPT2_HUMAN
Alternative names:
Neural precursor cell expressed developmentally down-regulated protein 5
Alternative UPACC:
Q15019; B4DGE8; Q14132; Q53QU3; Q8IUK9; Q96CB0
Background:
Septin-2, also known as Neural precursor cell expressed developmentally down-regulated protein 5, is a pivotal filament-forming cytoskeletal GTPase. It collaborates with SEPTIN12, SEPTIN6, SEPTIN2, and SEPTIN4 in sperm tail structure and motility. Beyond reproductive biology, Septin-2 is integral to actin cytoskeleton organization, mitotic progression, and ciliogenesis, underscoring its role in cellular architecture and division.
Therapeutic significance:
Understanding the role of Septin-2 could open doors to potential therapeutic strategies. Its involvement in critical cellular processes such as mitosis and ciliogenesis makes it a compelling target for drug discovery, aiming to address disorders stemming from cellular architecture abnormalities.