Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q15477
UPID:
SKI2_HUMAN
Alternative names:
Helicase-like protein
Alternative UPACC:
Q15477; O15005; Q12902; Q15476; Q5ST66
Background:
Superkiller complex protein 2, also known as Helicase-like protein, plays a pivotal role in mRNA decay and quality control. It is a crucial component of the SKI complex, facilitating mRNA extraction from ribosomes and directing it towards degradation. This protein's involvement in ribosome recycling and its association with transcriptionally active genes underscore its significance in cellular processes.
Therapeutic significance:
The protein is linked to Trichohepatoenteric syndrome 2, a condition marked by growth retardation, severe diarrhea, and immunodeficiency. Understanding the role of Superkiller complex protein 2 could open doors to potential therapeutic strategies for this syndrome.