Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q15633
UPID:
TRBP2_HUMAN
Alternative names:
TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein
Alternative UPACC:
Q15633; Q12878; Q8WY32; Q8WY33; Q9BRY2
Background:
RISC-loading complex subunit TARBP2, also known as TAR RNA-binding protein 2, plays a crucial role in RNA silencing. It is a key component of the RISC loading complex, essential for processing precursor miRNAs to mature miRNAs and their subsequent loading onto AGO2. This process is vital for the formation of the minimal RISC, which is instrumental in gene silencing. Additionally, TARBP2 binds to HIV-1 TAR RNA, stimulating translation of TAR-containing RNAs and mediating immune evasion by promoting 2'-O-methylation of the viral genome.
Therapeutic significance:
Understanding the role of RISC-loading complex subunit TARBP2 could open doors to potential therapeutic strategies.