Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q15642
UPID:
CIP4_HUMAN
Alternative names:
Protein Felic; Salt tolerant protein; Thyroid receptor-interacting protein 10
Alternative UPACC:
Q15642; B2R8A6; B7WP22; D6W645; O15184; Q53G22; Q5TZN1; Q6FI24; Q8NFL1; Q8TCY1; Q8TDX3; Q96RJ1
Background:
Cdc42-interacting protein 4, also known as Protein Felic, Salt tolerant protein, and Thyroid receptor-interacting protein 10, plays a crucial role in cellular processes. It is essential for the translocation of GLUT4 to the plasma membrane in response to insulin signaling, coordinating membrane tubulation with actin cytoskeleton reorganization during endocytosis. This protein binds to specific lipids, promoting membrane invagination and tubule formation, and facilitates CDC42-induced actin polymerization, crucial for endocytic vesicle formation and podosome formation in monocyte-derived cells.
Therapeutic significance:
Understanding the role of Cdc42-interacting protein 4 could open doors to potential therapeutic strategies.