Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q16288
UPID:
NTRK3_HUMAN
Alternative names:
GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase
Alternative UPACC:
Q16288; B7Z4C5; E9PG56; H0YND1; O75682; Q12827; Q16289
Background:
The NT-3 growth factor receptor, also known as Neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase, plays a pivotal role in the development of the nervous system and possibly the heart. It functions by binding to its ligand NTF3/neurotrophin-3, leading to autophosphorylation and activation of signaling pathways such as phosphatidylinositol 3-kinase/AKT and MAPK, which are crucial for cell survival and differentiation.
Therapeutic significance:
Understanding the role of NT-3 growth factor receptor could open doors to potential therapeutic strategies.