Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q16533
UPID:
SNPC1_HUMAN
Alternative names:
Proximal sequence element-binding transcription factor subunit gamma; Small nuclear RNA-activating complex polypeptide 1; snRNA-activating protein complex 43 kDa subunit
Alternative UPACC:
Q16533
Background:
The snRNA-activating protein complex subunit 1, also known as Proximal sequence element-binding transcription factor subunit gamma, plays a crucial role in gene transcription. It is a part of the SNAPc complex, essential for RNA polymerase II and III small-nuclear RNA genes transcription. This protein binds to the proximal sequence element (PSE), facilitating the recruitment of TBP and BRF2 to the U6 snRNA TATA box.
Therapeutic significance:
Understanding the role of snRNA-activating protein complex subunit 1 could open doors to potential therapeutic strategies.