AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for T-box brain protein 1

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our high-tech, dedicated method is applied to construct targeted libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q16650

UPID:

TBR1_HUMAN

Alternative names:

TES-56

Alternative UPACC:

Q16650; B0AZS4; B2R6G5; Q14DC5; Q53TH0; Q56A81

Background:

T-box brain protein 1 (TBR1), also known as TES-56, plays a pivotal role in cortical development. It functions as a transcriptional repressor, influencing neuronal migration, laminar and areal identity, and axonal projection. Specifically, TBR1 restricts the formation of the corticospinal tract from layer 6 projection neurons to layer 5 neurons, highlighting its critical role in brain architecture.

Therapeutic significance:

TBR1 is linked to Intellectual developmental disorder with autism and speech delay, a neurodevelopmental disorder characterized by intellectual disability, autism spectrum disorder, and language deficits. Understanding the role of TBR1 could open doors to potential therapeutic strategies for this condition.

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