Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q16706
UPID:
MA2A1_HUMAN
Alternative names:
Golgi alpha-mannosidase II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Alternative UPACC:
Q16706; Q16767
Background:
Alpha-mannosidase 2, known by alternative names such as Golgi alpha-mannosidase II and Mannosidase alpha class 2A member 1, plays a pivotal role in the biosynthesis of complex N-glycans. It is instrumental in the conversion of high mannose to complex N-glycans, marking the final hydrolytic step in the N-glycan maturation pathway.
Therapeutic significance:
Understanding the role of Alpha-mannosidase 2 could open doors to potential therapeutic strategies. Its critical function in the N-glycan maturation pathway highlights its importance in cellular processes and disease mechanisms.